Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programmed cell death in cerebral ischemia.

S H Graham1, J Chen

  • 1Department of Neurology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|February 15, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulation and immunolocalization of acyl-coenzyme A: cholesterol acyltransferase in mammalian cells as studied with specific antibodies.

The Journal of biological chemistry·1995
Same author

Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin.

Blood·1995
Same author

Operator-less processing of myocardial perfusion SPECT studies.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1995
Same author

Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments.

Molecular pharmacology·1995
Same author

T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice.

The Journal of experimental medicine·1995
Same author

Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes.

The Journal of biological chemistry·1995

Programmed cell death (PCD) plays a role in brain development and may contribute to neuronal cell death after ischemic injury. Investigating PCD pathways could lead to new stroke therapies.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Death Research

Background:

  • Programmed cell death (PCD) is a regulated process crucial for development.
  • Classical apoptosis is not always evident in ischemic brain injury.
  • Emerging evidence suggests PCD's role in pathological neuronal death.

Purpose of the Study:

  • Review molecular pathways of PCD in mammalian cells.
  • Explore the link between PCD and pathological neuronal cell death.
  • Assess PCD's contribution to ischemic brain injury.

Main Methods:

  • Review of existing literature on PCD molecular pathways.
  • Analysis of evidence for PCD in ischemic brain injury.
  • Examination of studies using genetic and pharmacologic tools to modulate PCD.

Related Experiment Videos

Main Results:

  • Altered expression and activity of key death-regulatory genes in ischemic brain.
  • Modulation of gene product activity impacts neuronal survival post-ischemia.
  • Strong support for PCD's contribution to ischemic neuronal death.

Conclusions:

  • PCD is implicated in neuronal cell death following ischemic injury.
  • Further research is needed to elucidate precise initiation and execution pathways.
  • Understanding these mechanisms may yield novel therapeutic strategies for stroke.