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Ketamine sedation for pediatric gastroenterology procedures
S M Green1, M Klooster, T Harris
1Department of Emergency Medicine, Loma Linda University Medical Center and Children's Hospital, California, USA. stevegreen@tarascon.com
Journal of Pediatric Gastroenterology and Nutrition
|February 15, 2001
Summary
Ketamine is a safe sedative for pediatric gastroenterology procedures, with laryngospasm being the main adverse effect, especially in younger children. This study evaluated ketamine
Area of Science:
- Pediatric Gastroenterology
- Sedation Management
- Pharmacology
Background:
- Ketamine is commonly used for pediatric procedural sedation.
- Its safety in pediatric gastroenterology is not well-established.
- This study reviews a 5-year experience with ketamine in this setting.
Purpose of the Study:
- To document the safety profile of ketamine for pediatric gastroenterology procedures.
- To identify predictors of laryngospasm during esophagogastroduodenoscopy (EGD).
Main Methods:
- Retrospective consecutive case series of children receiving ketamine.
- Data collected on indications, dosage, adverse effects, and recovery.
- Logistic regression analysis to identify laryngospasm predictors.
Main Results:
- Ketamine administered 636 times, primarily for EGD (86%).
- Adverse effects included transient laryngospasm (8.2%), emesis (4.1%), and recovery agitation (2.4%).
- Laryngospasm occurred in 9.5% of EGDs, primarily in preschool-aged children (<6 years).
Conclusions:
- Pediatric gastroenterologists can safely administer ketamine for GI procedures.
- Transient laryngospasm is the most common adverse event during EGD.
- Younger age is a predictor of laryngospasm in pediatric patients.