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Published on: February 7, 2018
Emotional state and one-trial learning in OXYS rats with hereditarily elevated production of oxygen radicals
1Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Bulletin of Experimental Biology and Medicine
|February 15, 2001
Abstract:
Comparative analysis of unconditioned and conditioned behavior of Wistar and prematurely aging OXYS rats revealed that the latter have significantly reduced locomotor and exploratory activities, increased anxiety in the elevated plus-maze test, spatial disorientation, and abnormal associative learning. OXYS rats can be used as a biological model for studying molecular, neurobiological, and neurochemical mechanisms of brain aging.
