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Updated: Oct 9, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
Published on: November 1, 2012
New relationship between electrical characteristics of evoked contractions in skeletal muscles during necrobiosis
1Department of General Pathology, I. M. Sechenov Moscow Medical Academy.
Abstract:
Evoked muscle contractions at different stages of necrobiosis were investigated by stimulating impedance myography in patients with vascular pathology and acute or chronic ischemic syndrome of the lower extremities. The threshold and maximum amplitudes and current strength for contraction responses were determined, and the dependence of evoked contractions on stimulating current was evaluated. Approximation of the obtained curves with the well-known force-time excitation curves demonstrated the relationship between excitability and contractility parameters depending on the stage of ischemic necrobiosis. This regularity is a more universal interrelation between muscle electrical characteristics. Electrical characteristics of evoked contractions depend on various factors influencing muscle structure and function.
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