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Trimetazidine as indirect antioxidant.

A K Tikhaze1, V Z Lankin, E A Zharova

  • 1Laboratory of Biochemistry of Free Radical Processes, A. L. Myasnikov Institute of Cardiology, Russian Cardiology Research-and-Production Complex, Russian Ministry of Health, Russia.

Bulletin of Experimental Biology and Medicine
|February 15, 2001
PubMed
Summary

Trimetazidine therapy reduced harmful oxidation products in coronary heart disease patients. This treatment also boosted antioxidant enzyme activity, suggesting a protective effect against ischemia-related damage.

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Area of Science:

  • Cardiology
  • Biochemistry
  • Pharmacology

Background:

  • Coronary heart disease (CHD) is associated with increased oxidative stress.
  • Atherogenic low-density lipoproteins (LDL) are susceptible to free radical oxidation.
  • Oxidative modification of LDL contributes to atherosclerosis progression.

Purpose of the Study:

  • To investigate the effect of trimetazidine on oxidative stress markers in patients with CHD.
  • To assess the impact of trimetazidine on antioxidant enzyme activity.

Main Methods:

  • Patients with CHD received one-month therapy with trimetazidine.
  • Levels of free radical oxidation products, including lipid peroxides and malonic dialdehyde, in LDL were measured.
  • Plasma glutathione peroxidase activity was assessed.

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Main Results:

  • Trimetazidine therapy significantly decreased lipid peroxides and malonic dialdehyde in LDL.
  • A marked increase in plasma glutathione peroxidase activity was observed during trimetazidine treatment.
  • These findings suggest trimetazidine attenuates adverse effects of free radical oxidation.

Conclusions:

  • Trimetazidine reduces oxidative stress in patients with coronary heart disease.
  • The cardioprotective effects of trimetazidine may be mediated by the activation of antioxidant enzymes.
  • Trimetazidine diminishes the negative consequences of ischemia through enhanced antioxidant defense.