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Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
Published on: May 7, 2012
Cytomegalovirus hemorrhagic gastritis
1Division of Gastroenterology, The George Washington University Medical Center, Washington, DC 20037, USA.
AIDS Patient Care and Stds
|February 15, 2001
Summary
Cytomegalovirus (CMV) disease of the stomach is rare in immunocompromised patients. This case highlights CMV gastritis presenting as severe nausea, vomiting, and hemorrhagic mucosa, successfully treated with ganciclovir.
Area of Science:
- Gastroenterology
- Virology
- Immunology
Background:
- Cytomegalovirus (CMV) infection is common in individuals with acquired immune deficiency syndrome (AIDS).
- Gastric involvement by CMV is uncommon, even in severely immunocompromised patients.
- Typical endoscopic findings of CMV gastritis include punched-out gastric ulcers.
Observation:
- A 36-year-old male with AIDS presented with intractable nausea and vomiting.
- Esophagogastroduodenoscopy revealed hemorrhagic and necrotic gastric mucosa without discrete ulcers.
- Histopathology confirmed viral inclusions indicative of CMV disease.
Findings:
- This case demonstrates a rare presentation of CMV disease affecting the stomach.
- The patient exhibited hemorrhagic, necrotic gastritis with inflammatory bridging, deviating from typical ulcer findings.
- Intravenous ganciclovir treatment for 6 weeks led to symptom resolution and normalization of endoscopic findings.
Implications:
- This case expands the spectrum of gastric cytomegaloviral disease presentations in immunocompromised individuals.
- It underscores the importance of considering CMV gastritis in AIDS patients with unexplained gastrointestinal symptoms.
- Prompt diagnosis and antiviral therapy are crucial for managing this rare but serious complication.
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