Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasticity of bone marrow-derived stem cells.

R Mertelsmann1

  • 1University Medical Center, Department of Hematology/Oncology, Hugstetter Str. 55, 79106 Freiburg, Germany. Mertelsmann@mm11.ukl.uni-freiburg.de

Journal of Hematotherapy & Stem Cell Research
|February 15, 2001
PubMed
Summary

Hematopoietic stem cell transplantation is shifting from myeloablative to immunosuppressive regimens. Stem cell plasticity offers new therapeutic strategies for various conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automatic feedback control by image processing for mixing solutions in a microfluidic device.

Biomicrofluidics·2022
Same author

Treatment of Philadelphia Chromosome Positive (Ph +) Chronic Myelogenous Leukemia in Blast Crisis and Ph + Acute Leukemia with High Dose Cytosine Arabinoside (HDARAC).

Leukemia & lymphoma·2016
Same author

[Current treatment concepts of lung cancer].

Deutsche medizinische Wochenschrift (1946)·2011
Same author

Long-term remission after CD34+-selected PBSCT in a patient with advanced intra-abdominal desmoplastic small round-cell tumor.

Bone marrow transplantation·2009
Same author

Prognosis of older patients with acute myeloid leukemia receiving either induction or noncurative treatment: a single-center retrospective study.

Annals of hematology·2003
Same author

[Continuous delivery of epidermal growth factor to wounds in vivo by genetically modified fibroblasts transfected with a novel chimeric construct].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·2002

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Immunology

Background:

  • Hematopoietic stem cell transplantation (HSCT) is evolving, moving away from high-dose myeloablative conditioning.
  • Current research focuses on immunosuppressive regimens that utilize donor lymphocytes for ablation.

Purpose of the Study:

  • To explore the evolving landscape of hematopoietic stem cell transplantation.
  • To highlight the concept of stem cell plasticity and its therapeutic implications.

Main Methods:

  • Review of recent advancements in conditioning regimens for HSCT.
  • Analysis of studies investigating stem cell differentiation and plasticity.

Main Results:

  • High-dose myeloablative conditioning is being replaced by immunosuppressive regimens.
  • Evidence suggests stem cells possess plasticity, differentiating into various non-hematopoietic and hematopoietic lineages.
  • This plasticity opens avenues for novel therapeutic strategies.

Conclusions:

  • The field of HSCT is undergoing a paradigm shift towards less intensive conditioning.
  • Stem cell plasticity represents a significant biological concept with potential for groundbreaking therapeutic applications.

Related Experiment Videos