Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Polymorphism in regulatory gene sequences.

N A Mitchison¹

¹Department of Immunology, Windeyer Institute of Medical Science, University College London Medical School, Cleveland Street, London W1P 6DB, UK. n.mitchison@ucl.ac.uk

|February 24, 2001

Summary

Genetic variations in non-coding gene regions, especially within the immune system, are more significant than previously thought. This discovery opens avenues for novel therapeutic strategies targeting these genetic elements.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

J. B. S. Haldane, as I knew him.

Journal of genetics·2017

Same author

The case for a functional nomenclature.

Immunology today·2014

Same author

The major histocompatibility complex: the modern synthesis.

Immunology today·2014

Same author

Tissue Transplantation.

Proceedings of the Royal Society of Medicine·2009

Same author

Inflammation at the interface of innate and acquired immunity.

Molecular immunology·2009

Same author

Aqueous humor alloreactive cell phenotypes, cytokines and chemokines in corneal allograft rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2008

Area of Science:

Genetics
Immunology
Genomics

Background:

Non-coding DNA was historically considered less significant than coding regions.
Gene regulation plays a critical role in cellular function and organismal development.
The immune system exhibits complex genetic regulation essential for its function.

Purpose of the Study:

To investigate the functional and evolutionary significance of genetic variations in non-coding gene-regulatory sequences.
To explore the role of polymorphism in immune system gene regulation.
To identify potential new therapeutic targets based on non-coding genetic variation.

Main Methods:

Analysis of extensive polymorphism data in non-coding gene-regulatory regions.
Comparative genomics to assess evolutionary conservation and variation.
Functional studies to evaluate the impact of identified polymorphisms on gene expression.

Main Results:

Demonstrated extensive polymorphism within non-coding gene-regulatory sequences.
Highlighted the particular prevalence and significance of such variations in the immune system.
Provided evidence for substantial functional and evolutionary importance of these non-coding variations.

Conclusions:

Polymorphism in non-coding gene-regulatory sequences is functionally and evolutionarily critical.
The immune system is a key area where these variations have significant implications.
These findings suggest new therapeutic strategies targeting non-coding genetic elements.

Related Experiment Videos