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Lymphoproliferative disorders after liver transplantation: imaging features
L Wu1, D C Rappaport, A Hanbidge
1Department of Medical Imaging, The Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.
Abdominal Imaging
|February 15, 2001
Summary
Post-transplant lymphoproliferative disorders (PTLDs) after liver transplantation present with diverse imaging findings. Key indicators include lymphadenopathy, portal masses, and bowel thickening, necessitating further investigation for diagnosis.
Area of Science:
- Transplant Surgery
- Oncology
- Radiology
Background:
- Lymphoproliferative disorders can occur following liver transplantation.
- Understanding their imaging characteristics is crucial for timely diagnosis.
Purpose of the Study:
- To define the imaging features of post-transplant lymphoproliferative disorders (PTLDs) in liver transplant recipients.
- To correlate imaging findings with clinical and pathological data.
Main Methods:
- Retrospective review of 605 liver transplantations performed between 1985 and 1998.
- Analysis of clinical, imaging, and pathological findings in 20 patients diagnosed with PTLDs.
Main Results:
- PTLDs were diagnosed in 20 patients (13 male, 7 female) with a mean age of 43.3 years.
- Common imaging findings included lymphadenopathy (55%) and complex portal masses (25%).
- Gastrointestinal involvement was observed in 15% of patients, manifesting as duodenal masses or bowel wall thickening.
Conclusions:
- Post-transplant lymphoproliferative disorders exhibit a wide spectrum of imaging manifestations.
- The presence of lymphadenopathy, portal mass, or bowel thickening warrants further investigation for pathological diagnosis.