[Morphological studies on the hepatotoxic effect of Thiuram (tetramethylthiuram disulphide) in white rats]

After a single per os or a single and repeated subcutan doses of Thiuram necrosis of the liver of different extension was revealed. Changes could be seen by 3--14 days after administration of Thiuram in different doses. In some cases animals died spontaneously. These investigations seems to evidence the fact that Thiuram, which is similar to Disulphiram (Antaethyl-Antabus) used in the therapy of chronic alkoholism in big doses exerts a noxious effect on the liver of white rats.