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Synthesis of 2-amino-3-fluoroacrylic acid containing peptides
1Department of Chemistry, University of Illinois at Urbana-Champaign, 61801, USA.
Organic Letters
|February 17, 2001
Abstract:
[reaction: see text] Peptides containing (E)- and (Z)-3-fluorodehydroalanine have been prepared from serine via a fluoro-Pummerer rearrangement. The resulting electrophilic moieties may be useful affinity labels for the identification of the targets of dehydroamino acid containing natural products that act by covalent mechanisms.