Related Experiment Videos
Water-soluble 99mTc-labeled dendritic novel porphyrins tumor imaging and diagnosis
M Subbarayan1, S J Shetty, T S Srivastava
1Radiation Medicine Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, 400 012, India.
Biochemical and Biophysical Research Communications
|February 17, 2001
Abstract:
We have synthesized two water soluble dendritic porphyrins, termed DP1 and DP2 and have successfully radiolabeled them with 99mTc. These 99mTc-labeled porphyrins were administered to C6-glioma tumor bearing Wistar rats and scintiimaging and biodistribution studies were carried out. Tumor to muscle ratios of DP1 and DP2 were 8.0 and 9.7, respectively. These molecules may have potential for tumor imaging and diagnosis and may even prove useful as photosensitizers in photodynamic therapy applications.