Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic behavior during noninvasive ventilation: chaotic support?

J R Hotchkiss1, A B Adams, D J Dries

  • 1Section of Pulmonary and Critical Care, Regions Hospital and University of Minnesota, St. Paul, Minnesota 55101, USA. John.R.Hotchkiss@HealthPartners.com

American Journal of Respiratory and Critical Care Medicine
|February 17, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical power guided lung protective ventilation in acute respiratory failure using the VentCoach approach.

Scientific reports·2026
Same author

Isn't it time to abandon ARDS? The COVID-19 lesson.

Critical care (London, England)·2021
Same author

Mechanical power at a glance: a simple surrogate for volume-controlled ventilation.

Intensive care medicine experimental·2019
Same author

The Language of Caring: Quantitating Medical Practice Patterns using Symbolic Dynamics.

Mathematical modelling of natural phenomena·2018
Same author

Belatacept Combined With Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long-Term Renal Allograft Function.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Increased Pretransplant Frequency of CD28<sup>+</sup> CD4<sup>+</sup> T<sub>EM</sub> Predicts Belatacept-Resistant Rejection in Human Renal Transplant Recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same journal

Opportunities for Human Lung Tissue-Based Studies in Fibrotic ILD Research.

American journal of respiratory and critical care medicine·2026
Same journal

Astegolimab in COPD: success or failure?

American journal of respiratory and critical care medicine·2026
Same journal

How artificial intelligence could improve the diagnosis and management of COPD: a perspective from GOLD.

American journal of respiratory and critical care medicine·2026
Same journal

Awake ECMO for ARDS: No Vent, No VILI, No Problem?

American journal of respiratory and critical care medicine·2026
Same journal

Microbiome-Targeted Antibiotics Provide No Additional Microbiologic or Inflammatory Benefit during Cystic Fibrosis Pulmonary Exacerbations: Results from the CFMATTERS Trial.

American journal of respiratory and critical care medicine·2026
Same journal

Noninvasive Respiratory Support for Adult Patients with Acute Respiratory Failure. An Official American Thoracic Society Clinical Practice Guideline.

American journal of respiratory and critical care medicine·2026
See all related articles

Mask leaks during noninvasive ventilation can cause unstable breathing support. This study used models and tests to show how leaks affect pressure support, leading to variable breathing duration and autoPEEP.

Area of Science:

  • Respiratory physiology
  • Biomedical engineering

Background:

  • Noninvasive ventilation (NIV) commonly uses face masks with pressure support.
  • Mask leaks are a frequent issue in NIV, potentially affecting ventilator performance.

Purpose of the Study:

  • To investigate the impact of mask leaks on the dynamic behavior of pressure-supported NIV.
  • To analyze how leaks influence inspiratory phase termination and autoPositive End-Expiratory Pressure (autoPEEP).

Main Methods:

  • Development of a mathematical model to simulate pressure-supported NIV with inspiratory leaks.
  • Validation of the mathematical model using a test lung system.
  • Analysis of ventilator settings and impedance values for clinical relevance.

Main Results:

Related Experiment Videos

  • Mathematical and laboratory analyses demonstrated marked variations in inspiratory phase duration with leaks.
  • Unstable ventilator behavior, including variable autoPEEP, was observed even with consistent patient effort.
  • The observed instability occurred at clinically realistic impedance and ventilator settings.

Conclusions:

  • Inspiratory mask leaks in pressure-supported NIV can lead to significant instability in ventilation delivery.
  • This instability can manifest as unpredictable changes in breathing support and autoPEEP.
  • The findings highlight the importance of addressing mask leak issues for effective NIV therapy.