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Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon
T Kawakami1, T Tokunaga, H Hatanaka
1Department of Pathology, Tokai University, School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Abstract:
Interleukin 10 (IL-10) is an immuno-suppressive cytokine produced by T-lymphocytes, and a regulatory molecule for angiogenesis in various cancers. We examined IL-10 gene expression in 53 colon cancer patients who underwent surgical resection. IL-10 gene expression was correlated with TSP1 and TSP2 gene expression (P=0.0049, P=0.0285). Colon cancer with IL-10 gene expression (19/53) showed significantly decreased venous involvement (P=0.0433). The mean vessel counts in the colon cancers with IL-10 gene expression were significantly lower than those without IL-10 gene expression (P<0.001). These results suggested that IL-10 stimulates angiostatic factor gene expression, and results in suppression of venous involvement.