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Effectiveness of pharmacomechanical thrombolysis in infants and children

A Robinson1, K E Fellows, N D Bridges

  • 1Cardiac Center at the Children's Hospital of Philadelphia, and the Department of Pediatrics, The University of Pennsylvania School of Medicine, USA.

The American Journal of Cardiology
|February 17, 2001
PubMed

Insights

Pharmacomechanical thrombolysis effectively treated major thromboses in 10 children. Most patients showed clinical improvement, with significant thrombus resolution observed in follow-up angiography.

Area of Science:

  • Pediatric Thrombosis
  • Interventional Cardiology
  • Vascular Medicine

Background:

  • Major thromboses pose significant risks in pediatric patients.
  • Effective treatment strategies for pediatric thrombosis are crucial for long-term outcomes.

Purpose of the Study:

  • To evaluate the efficacy and outcomes of local pharmacomechanical thrombolysis in children with major thromboses.

Main Methods:

  • A cohort of 10 pediatric patients with major thromboses underwent local pharmacomechanical thrombolysis between March 1995 and February 2000.
  • Clinical improvement was assessed, and follow-up angiography was performed to evaluate thrombus resolution.

Main Results:

  • Clinical improvement was observed in 8 out of 10 treated children.
  • Complete thrombus resolution was achieved in 5 patients, and subtotal resolution in 4 patients following treatment.

Conclusions:

  • Local pharmacomechanical thrombolysis appears to be an effective treatment for major thromboses in pediatric patients.
  • The procedure demonstrated a high rate of clinical improvement and significant thrombus resolution in the studied cohort.

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