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HCV infection in Poland.

K Bielawski1, M Wlasiuk, M Truskolawska

  • 1Department of Laboratory Medicine, Provincial Infectious Diseases Hospital at Gdansk, Gdansk, Poland.

Archives of Medical Research
|February 17, 2001
PubMed
Summary

This study found that 1.9% of the Polish population has Hepatitis C virus (HCV) infection markers, with higher prevalence in men. This research provides a realistic estimate of HCV infection in Poland.

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Area of Science:

  • Hepatology
  • Virology
  • Epidemiology

Background:

  • Hepatitis C virus (HCV) infection is a global health concern.
  • Hepatitis C became a statutorily notifiable disease in Poland in 1997.
  • Limited data exists on HCV prevalence in the Polish general population.

Purpose of the Study:

  • To determine the prevalence of HCV infection markers in an unselected Polish population.
  • To assess the prevalence of anti-HCV IgG antibodies and HCV-RNA.
  • To analyze the relationship between HCV markers and demographic factors.

Main Methods:

  • Serum samples from 2,561 volunteers were collected after public advertisements for free testing.
  • Anti-HCV IgG antibodies were detected using third-generation enzyme immunoassay.
  • HCV-RNA was determined by reverse transcription-polymerase chain reaction (RT-PCR) in anti-HCV positive samples.

Main Results:

  • Anti-HCV IgG was detected in 1.9% of subjects (48/2561).
  • Prevalence was significantly higher in men (2.3%) than women (1.7%) (p=0.0057).
  • HCV-RNA was present in 65% (31/48) of anti-HCV positive cases, with no significant demographic correlations.

Conclusions:

  • This is the largest study on HCV prevalence in the general Polish population to date.
  • Despite limitations like a non-randomized sample, results offer a realistic estimate of HCV infection.
  • Findings contribute valuable data for public health strategies in Poland.

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