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Related Experiment Videos

Paraventricular hypothalamic alpha-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive

M M Wirth1, P K Olszewski, C Yu

  • 1Minnesota Obesity Center, V.A. Medical Center, One Veterans Drive, 55417, Minneapolis, MN, USA

Peptides
|February 17, 2001
PubMed
Summary

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alpha-Melanocyte-stimulating hormone (alpha-MSH) and MTII reduce food intake by acting on the paraventricular nucleus (PVN). These melanocortin receptor agonists do not cause aversive effects when administered locally into the PVN.

Area of Science:

  • Neuroendocrinology
  • Appetite Regulation
  • Pharmacology

Background:

  • alpha-Melanocyte-stimulating hormone (alpha-MSH) is implicated in regulating feeding behavior and energy balance.
  • Synthetic melanocortin receptor 3 and 4 (MC3-R/MC4-R) agonists, like MTII, mimic alpha-MSH effects on feeding.

Purpose of the Study:

  • To investigate the effects of alpha-MSH and MTII on food intake when administered into the paraventricular nucleus (PVN).
  • To determine if these effects are associated with aversive outcomes, such as conditioned taste aversion (CTA).

Main Methods:

  • Rats were administered alpha-MSH or MTII directly into the PVN.
  • Food intake was measured during nocturnal feeding and in response to Neuropeptide Y (NPY) stimulation.
  • Conditioned taste aversion (CTA) was assessed following PVN or intracerebroventricular (ICV) administration of the compounds.

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Main Results:

  • PVN administration of alpha-MSH and MTII significantly decreased both nocturnal and NPY-stimulated food intake.
  • Local PVN administration of alpha-MSH or MTII did not induce CTA.
  • ICV administration of alpha-MSH, however, resulted in a weak CTA.

Conclusions:

  • The anorectic effects of alpha-MSH and MTII in the PVN are not mediated by aversive mechanisms.
  • The PVN is a critical site for the inhibitory action of melanocortin agonists on feeding behavior.