Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

Cerebrum: Anatomical Overview I

Cerebrum: Anatomical Overview I

The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...

Cerebrum: Anatomical Overview II

Cerebrum: Anatomical Overview II

Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...

Cerebellum: Anatomical Regions

Cerebellum: Anatomical Regions

The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

Role of Cerebellum and Prefrontal Cortex in Memory

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the cerebellum's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intravitreal triamcinolone and elevated intraocular pressure.

Australian and New Zealand journal of ophthalmology·2000

Same author

The role of the rhombic lip in avian cerebellum development.

Development (Cambridge, England)·1999

Same author

Neurogenetics of the cerebellar system.

Journal of child neurology·1999

Same author

Microscopy and photomicrography techniques.

Methods in molecular biology (Clifton, N.J.)·1999

Same author

Homeotic transformation of rhombomere identity after localized Hoxb1 misexpression.

Science (New York, N.Y.)·1999

Same author

Tlx-1 and Tlx-3 homeobox gene expression in cranial sensory ganglia and hindbrain of the chick embryo: markers of patterned connectivity.

The Journal of neuroscience : the official journal of the Society for Neuroscience·1998

Search research articles

Related Experiment Video

Updated: Jul 22, 2026

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos

Published on: August 3, 2012

The rhombic lip and early cerebellar development.

¹MRC Centre for Developmental Neurobiology, King's College London, 4th floor New Hunt's House, Guy's Campus, London SE1 1UL, UK. richard.wingate@kcl.ac.uk

Current Opinion in Neurobiology

|February 17, 2001

Summary

The embryonic rhombic lip

Area of Science:

Neurodevelopmental biology
Developmental neuroscience
Embryology

Background:

The embryonic rhombic lip is crucial for forming specific brain structures.
Its developmental mechanisms were not fully understood.
Recent research has shed light on its patterning and derivatives.

Purpose of the Study:

To elucidate the inductive cues and guidance molecules involved in rhombic lip development.
To understand the regional origins and migratory pathways of rhombic lip derivatives.
To explore the role of the rhombic lip in generating neural systems.

Main Methods:

Analysis of embryonic development.
Identification of signaling pathways.
Tracing cell migration patterns.

More Related Videos

Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors

Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors

Published on: December 14, 2015

Modeling Human Cerebellar Development In Vitro in 2D Structure

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

Related Experiment Videos

Last Updated: Jul 22, 2026

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos

Published on: August 3, 2012

Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors

Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors

Published on: December 14, 2015

Modeling Human Cerebellar Development In Vitro in 2D Structure

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

Main Results:

Specific anteroposterior and dorsalizing cues pattern cerebellar development.
Netrin guides the migration of hindbrain rhombic lip derivatives to form precerebellar nuclei.
The rhombic lip acts as a distinct epithelium with late developmental and evolutionary appearance.

Conclusions:

The rhombic lip is a key signaling center in embryonic brain development.
Its unique spatiotemporal characteristics are vital for constructing complex neural systems.
Understanding rhombic lip development provides insights into neurodevelopmental disorders.