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Related Experiment Videos

Rho GTPases in growth cone guidance.

B J Dickson1

  • 1Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. dickson@nt.imp.univie.ac.at

Current Opinion in Neurobiology
|February 17, 2001
PubMed
Summary
This summary is machine-generated.

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Small GTPases, including Rac, Cdc42, and Rho, are crucial for growth cone morphology and guidance. New evidence shows these proteins play an instructive role in transducing extracellular guidance signals.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • The Rho family of small GTPases (Rac, Cdc42, Rho) are known regulators of growth cone morphology.
  • Their precise role in growth cone guidance, whether permissive or instructive, remains less understood.

Purpose of the Study:

  • To investigate the role of Rho GTPases in transducing extracellular guidance cues for growth cone navigation.
  • To elucidate the mechanisms by which Rho GTPases influence growth cone guidance.

Main Methods:

  • In vitro studies examining the modulation of Rho GTPase activity by extracellular guidance cues.
  • In vivo studies assessing the function of Rho GTPase activators in growth cone guidance.

Main Results:

Related Experiment Videos

  • Extracellular guidance cues were shown to modulate Rho GTPase activities in vitro.
  • Rho GTPase activators were demonstrated to be functional in growth cone guidance in vivo.
  • Pathways linking Rho GTPases and the actin cytoskeleton, regulated by extracellular cues, are being identified.

    • Conclusions:

    • Rho GTPases play an instructive role in growth cone guidance by transducing extracellular signals.
    • Growth cone guidance involves signals mediated both through and independently of Rho GTPases.