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Published on: February 16, 2018
Combinatorial and Evolution-Based Methods in the Creation of Enantioselective Catalysts
1Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 1 45470 Mülheim an der Ruhr (Germany).
Angewandte Chemie (International Ed. in English)
|February 17, 2001
Summary
Combinatorial chemistry accelerates the discovery of asymmetric catalysts by creating diverse ligand libraries. High-throughput screening methods, including mass spectrometry and capillary electrophoresis, enable rapid enantioselectivity assessment.
Area of Science:
- Catalysis
- Organic Chemistry
- Chemical Engineering
Background:
- Combinatorial methods offer a novel approach to developing enantioselective homogeneous catalysts.
- This contrasts with traditional single-catalyst development, aiming to accelerate discovery through parallel synthesis and screening.
- Modularly constructed ligands on solid supports are key for generating diverse chiral ligand libraries.
Purpose of the Study:
- To explore the application of combinatorial methods and high-throughput screening in discovering new asymmetric catalysts.
- To investigate advancements in parallel synthesis of chiral ligands and their screening for enantioselectivity.
- To highlight the role of analytical techniques in facilitating the search for novel catalysts and enzyme evolution.
Main Methods:
- Parallel synthesis of chiral ligand libraries using modular solid-support strategies.
- Development and application of high-throughput screening systems for enantioselectivity assessment.
- Utilizing techniques such as mass spectrometry (MS) and capillary electrophoresis (CE) for rapid enantiomeric excess (ee) determinations.
Main Results:
- Combinatorial strategies enable the preparation and screening of thousands of potential catalysts.
- High-throughput screening systems, like MS-based pseudo-enantiomer detection and capillary array electrophoresis, achieve high throughput (1000-30,000 ee determinations/day).
- These methods facilitate the discovery of catalysts not likely found by traditional approaches and aid enzyme evolution.
Conclusions:
- Combinatorial chemistry and high-throughput screening are powerful tools for discovering enantioselective homogeneous catalysts.
- Advancements in analytical technologies are crucial for enabling super-high-throughput screening.
- These integrated approaches are expected to drive significant progress in asymmetric catalysis and biocatalysis for organic chemistry.
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