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Economic evaluation alongside n-of-1 trials: getting closer to the margin
1Health Economics Research Group, Brunel University, Uxbridge, UK. hesrjdk@brunel.ac.uk
Health Economics
|February 17, 2001
Abstract:
The n-of-1 trial is a particularly flexible form of randomized controlled trial that involves a single patient receiving multiple episodes of alternative therapies. Although n-of-1 trials are only applicable in certain treatment areas, the collection of economic data within such trials may provide unique advantages. This paper illustrates the issues around the use of economic n-of-1 trials with a hypothetical example, and discusses their potential for the estimation of individualized cost-effectiveness.