The atypical presentation of tiaprofenic acid-induced cystitis

This retrospective review was carried out to investigate the clinical characteristics and outcomes of 7 patients presenting with non-bacterial cystitis. Patient demographics were different from the usual interstitial cystitis patient population. Each patient was being treated with tiaprofenic acid for arthritis at the time of presentation. After failure of initial medical therapy carried out elsewhere for presumed diagnosis of non-bacterial cystitis or interstitial cystitis, tiaprofenic acid was discontinued and symptoms improved or resolved in all patients obviating further, more morbid treatments. This small group of patients adds to the growing evidence that tiaprofenic acid causes a drug-induced cystitis which is effectively treated by discontinuation of the medication. A high index of suspicion for a drug-induced cause for the symptoms is important for the correct diagnosis and management of these patients.