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Endometrial dating correlated with progesterone levels
Obstetrics and Gynecology
|February 1, 1975
Summary
Measuring plasma progesterone levels is a valid and simple alternative to endometrial biopsies for confirming ovulation. Elevated progesterone confirms a mature secretory endometrium, indicating successful ovulation during the menstrual cycle.
Area of Science:
- Reproductive Endocrinology
- Gynecologic Pathology
Background:
- Endometrial biopsy is a traditional method for confirming ovulation.
- Assessing the luteal phase accurately is crucial for reproductive health evaluations.
Purpose of the Study:
- To validate progesterone determination as a substitute for endometrial biopsies in confirming ovulation.
- To assess the utility of progesterone assays in evaluating corpus luteum function.
Main Methods:
- Radioimmunoassay (RIA) was used to quantify plasma progesterone levels.
- Endometrial histology was performed for classical dating and comparison.
Main Results:
- Plasma progesterone levels > 2 ng/ml consistently correlated with a secretory endometrium.
- This indicates endometrial maturation beyond day 14 of the menstrual cycle.
- The RIA method for progesterone is simple and effective.
Conclusions:
- Progesterone measurement is a valid and simpler method than endometrial biopsy for confirming ovulation.
- This technique is valuable for assessing both normal and abnormal corpus luteum function.