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[Vertical transmission of hepatitis C virus]

C Rubio Quevedo1, M A Holgado Carballo, A García Suárez

  • 1Servicio de Pediatría. Hospital MaternoInfantil Virgen de las Nieves. Granada. claudiorq@teleline.es

Anales Espanoles De Pediatria
|February 22, 2001
PubMed

Insights

Vertical transmission of hepatitis C virus (HCV) occurs in about 5.7% of infants born to infected mothers. Risk factors like HCV/HIV coinfection increase transmission rates, highlighting the need for further research.

Area of Science:

  • Hepatology
  • Virology
  • Pediatrics

Context:

  • Hepatitis C virus (HCV) infection is a significant global health concern.
  • Vertical transmission is the primary route of HCV infection in children.
  • Limited data exists on the rate and risk factors of mother-to-child HCV transmission.

Purpose:

  • To determine the rate of vertical hepatitis C virus (HCV) transmission in at-risk neonates.
  • To assess the influence of maternal risk factors on HCV transmission to infants.
  • To evaluate the prevalence of HCV infection in children born to HCV-seropositive mothers.

Summary:

  • A prospective study followed 35 infants born to HCV-seropositive mothers.
  • HCV infection was confirmed in 5.7% of infants.
  • Maternal risk factors including parenteral exposure and HIV coinfection were associated with increased transmission risk.

Impact:

  • The study confirms a vertical HCV transmission rate of approximately 5%.
  • Identifies maternal HCV/HIV coinfection and parenteral risk factors as significant contributors to transmission.
  • Emphasizes the need for larger studies to ascertain HCV prevalence in pregnant women and refine transmission rates.
Abstract

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