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[Acute phase response after stroke: differences between ischemic stroke and intracerebral hemorrhage]
Montaner1, J Alvarez-Sabín, S Abilleira
1Unidad Cerebrovascular. Servicio de Neurología. Hospital Vall d'Hebron. Barcelona.
Medicina Clinica
|February 22, 2001
Summary
The acute phase response (APR) temporal profile differs between ischemic stroke (IS) and intracerebral hemorrhage (ICH). Leukocyte and fibrinogen increases are significantly higher in ICH patients compared to IS patients.
Area of Science:
- Neurology
- Immunology
- Biochemistry
Background:
- Acute phase response (APR) is a systemic reaction to tissue injury.
- Understanding the temporal dynamics of APR in different stroke types is crucial for diagnosis and management.
Purpose of the Study:
- To compare the temporal profile of the acute phase response (APR) between ischemic stroke (IS) and intracerebral hemorrhage (ICH).
Main Methods:
- Studied APR parameters at < 24 hours and 3-5 days in 88 patients (43 ICH, 45 IS).
- Analyzed the increase/decrease of APR parameters between these time points.
Main Results:
- Leukocyte increase (LI) was significantly higher in ICH compared to IS (p=0.047).
- Fibrinogen increase (FI) was significantly higher in ICH compared to IS (p=0.035).
Conclusions:
- The temporal profile of the acute phase response (APR) is distinct for intracerebral hemorrhage (ICH) and ischemic stroke (IS).
- Elevated LI and FI in the early phase suggest a more pronounced inflammatory response in ICH.