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Related Experiment Videos

Molecular analysis of Tn1546-like elements in vancomycin-resistant enterococci isolated from patients in Europe shows

M A Schouten1, R J Willems, W A Kraak

  • 1Department of Medical Microbiology, University Hospital St. Radboud, 6500 HB Nijmegen, The Netherlands. rschouten@rijnstate.nl

Antimicrobial Agents and Chemotherapy
|February 22, 2001
PubMed
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Two vancomycin-resistant enterococci lineages were identified in European clinical samples. These lineages, linked to animal colonization and meat consumption, show distinct geographic distributions across Europe, the UK, and Israel.

Area of Science:

  • Microbiology
  • Genetics
  • Epidemiology

Background:

  • Vancomycin-resistant enterococci (VRE) are a significant public health concern.
  • The vanA gene confers resistance to vancomycin, a critical antibiotic.
  • Understanding the genetic relatedness and evolution of VRE is crucial for infection control.

Purpose of the Study:

  • To investigate the resistance mechanism relatedness among clinical vanA vancomycin-resistant enterococci isolates from Europe.
  • To identify distinct evolutionary lineages of vanA VRE.
  • To explore the potential association between geographic distribution, animal colonization, and meat consumption patterns.

Main Methods:

  • Molecular analysis of 18 clinical vanA vancomycin-resistant enterococci isolates.
  • Identification and characterization of Tn1546-like elements.

Related Experiment Videos

  • Phylogenetic analysis to determine evolutionary lineages.

    • Main Results:

    • Ten Tn1546-like elements were identified, indicating two major evolutionary lineages.
    • Lineage I was predominantly found in European mainland isolates.
    • Lineage II was prevalent in isolates from the United Kingdom and Israel.
    • Geographic clustering correlated with differences in meat consumption and animal colonization patterns.

    Conclusions:

    • Two distinct evolutionary lineages of vanA VRE exist within Europe, the UK, and Israel.
    • The spread and distribution of these lineages are associated with specific animal reservoirs and human consumption habits.
    • Further research into the One Health aspect of VRE transmission is warranted.