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Related Experiment Videos

Plasma soluble Fas ligand concentration: decrease in elderly men and increase in patients with gastric carcinoma.

T Ichikura1, T Majima, T Uchida

  • 1The Department of Surgery I, National Defense Medical College Hospital, Tokorozawa 359-8513, Japan. ichikura@me.ndmc.ac.jp

Oncology Reports
|February 22, 2001
PubMed
Summary
This summary is machine-generated.

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Plasma soluble Fas ligand (sFasL) levels are higher in gastric cancer patients than healthy individuals, particularly in older males. Age and gender significantly influence sFasL concentrations, necessitating matched controls in research.

Area of Science:

  • Immunology
  • Oncology
  • Biochemistry

Background:

  • Fas ligand (FasL) induces apoptosis in Fas-expressing cells and is found on cancer cells.
  • Membrane-bound FasL is cleaved into soluble FasL (sFasL).
  • Limited data exists on sFasL concentrations in healthy individuals and carcinoma patients.

Purpose of the Study:

  • To measure and compare plasma sFasL concentrations in healthy volunteers and gastric carcinoma patients.
  • To investigate the correlation of plasma sFasL with age, gender, and gastric cancer stage.

Main Methods:

  • Plasma sFasL concentrations were measured using an enzyme-linked immunosorbent assay (ELISA).
  • 155 healthy volunteers (70 males, 85 females; avg age 41.5) and 112 gastric carcinoma patients (76 males, 36 females; avg age 62.3) were analyzed.

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  • Statistical analysis was performed to assess correlations and differences between groups.

    • Main Results:

    • A negative correlation between age and plasma sFasL was observed in healthy volunteers.
    • Male subjects had significantly lower sFasL concentrations than females.
    • Gastric carcinoma patients (males ≥ 50 years) exhibited significantly higher plasma sFasL than healthy controls.
    • In male patients (≥ 50 years), higher sFasL levels correlated with earlier tumor stages (1B/2) compared to advanced stages (3/4).

    Conclusions:

    • Age- and gender-matched controls are crucial for plasma sFasL concentration studies.
    • The physiological and clinical significance of plasma sFasL in healthy individuals and gastric cancer patients requires further investigation.