Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Remote functionalization reactions in steroids.

P B Reese1

  • 1Chemistry Department, University of the West Indies, Mona, Kingston 7, Jamaica, West Indies, Jamaica. pbreese@uwimona.edu.jm

Steroids
|February 22, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eryngial (trans-2-dodecenal), a bioactive compound from Eryngium foetidum: its identification, chemical isolation, characterization and comparison with ivermectin in vitro.

Parasitology·2013
Same author

Biotransformation of squamulosone by Curvularia lunata ATCC 12017.

Phytochemistry·2001
Same author

Biotransformation of cedrol by Curvularia lunata ATCC 12017.

Phytochemistry·2001
Same author

Biotransformation of diterpenes and diterpene derivatives by Beauveria bassiana ATCC 7159.

Phytochemistry·2001
Same author

New skeletal sesquiterpenoids, caprariolides A-D, from Capraria biflora and their insecticidal activity.

Journal of natural products·2000
Same author

Biotransformation of cadinane sesquiterpenes by Beauveria bassiana ATCC 7159.

Phytochemistry·2000
Same journal

Steroidal alkaloids as multi-target therapeutics for the treatment of endometriosis.

Steroids·2026
Same journal

Emerging trends for therapeutic valuation of Cyclopamine: Structural features, mechanism of action, and formulation strategies.

Steroids·2026
Same journal

The antiproliferative and antimigratory properties of the 3-biotin-B-norcholesteryl benzimidazole derivative in MCF-7 cells are mediated through G1 phase arrest and apoptosis.

Steroids·2026
Same journal

Development and validation of an LC-MS method for quantification of sex steroid hormones in skeletal muscle.

Steroids·2026
Same journal

Circulating 4β-hydroxycholesterol as a biomarker of CYP3A4 activity: beyond drug development.

Steroids·2026
Same journal

Impact of glycosylation position on flavonoid isomers' inhibition of breast cancer-associated enzyme CYP1B1.

Steroids·2026
See all related articles

This review covers thirty years of research on modifying unactivated positions in steroid molecules. It highlights advancements in steroid skeleton functionalization for various applications.

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • Steroid Chemistry

Background:

  • Steroids are crucial biomolecules with diverse physiological roles.
  • Functionalization of the steroid skeleton is key to developing new therapeutics.
  • Unactivated positions in steroids present synthetic challenges.

Purpose of the Study:

  • To review the progress in functionalizing unactivated steroid positions over the past 30 years.
  • To consolidate knowledge on synthetic methodologies for steroid modification.
  • To identify trends and future directions in steroid chemistry.

Main Methods:

  • Comprehensive literature search of scientific databases.
  • Analysis of synthetic strategies for steroid functionalization.

Related Experiment Videos

  • Categorization of methods based on the targeted steroid position.

    • Main Results:

    • Significant advancements in regioselective and stereoselective functionalization techniques.
    • Development of novel catalytic systems for C-H activation in steroids.
    • Expansion of the scope of reactions applicable to unactivated steroid positions.

    Conclusions:

    • The functionalization of unactivated steroid positions has matured significantly.
    • New synthetic tools enable precise modification of the steroid core.
    • Continued innovation promises novel steroid-based drugs and materials.