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Generating diversity at GABAergic synapses
1Biophysics Sector, International School of Advanced Studies, I-34014 Trieste, Italy.
Trends in Neurosciences
|February 22, 2001
Abstract:
GABA-mediated transmission is characterized by high variability of synaptic responses. Major contributors to this variability are: presynaptic factors, including release probability and number of release sites; factors that determine synaptic GABA transients in the cleft, including diffusion and the actions of GABA transporters; and postsynaptic factors, including GABA(A) receptors subtypes, their location and number, their modulation by endogenous and exogenous factors, and their interactions with postsynaptic-anchoring proteins.