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3-[123I]iodo-alpha-methyl-L-tyrosine transport and 4F2 antigen expression in human glioma cells
K J Langen1, R Bonnie, H Mühlensiepen
1Institute of Medicine, Research Center Jülich GmbH, D-52425, Jülich, Germany. k.j.langen@fz-juelich.de
Nuclear Medicine and Biology
|February 22, 2001
Abstract:
3[(123)I]iodo-alpha-methyl-L-tyrosine is a tracer of amino acid transport in brain tumors using single-photon emission-computed tomography and predominantly transported by amino acid transport system L. The 4F2 antigen has been identified to be linked to system L-like transport and is assumed to be a part of the transporter protein. We demonstrated that system L-mediated transport of IMT and 4F2 antigen expression are dependent on proliferation rate of human glioma cells and significantly correlated with each other.