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A new approach to antiplatelet therapy: inhibitor of GPIb/V/IX-vWF interaction

Y Ikeda1, M Handa, M Murata

  • 1Department of Internal Medicine and Blood Center, Keio University School of Medicine, Tokyo, Japan. yikeda@med.keio.au.jp

Haemostasis
|February 22, 2001
PubMed

Evidence has been presented that the interaction between von Willebrand factor (vWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis. A monoclonal antibody against the A1 domain of vWF has been shown to inhibit thrombus formation in the animal model of arterial thrombosis. Based upon these findings, a new approach to treating arterial thrombosis has been proposed by intervening in the interaction between vWF and platelet.

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