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Therapeutic progress of two sibling cases exhibiting sleep-wake rhythm disorder
M Mukai1, N Uchimura, N Takeuchi
1Department of Neuropsychiatry, Kurume University, School of Medicine, Fukuoka, Japan. mukai.m@dream.ocn.ne.jp
Psychiatry and Clinical Neurosciences
|February 24, 2001
Abstract:
In this study, two females, siblings who exhibited a non-24 h sleep-wake rhythm (non-24 h) at home were observed. However, they showed a delayed sleep phase syndrome (DSPS) immediately after admission to Kurume University Hospital. Melatonin (3 mg) was commenced following chronotherapy and this improved their sleep-wake rhythm. Polysomnography (PSG) showed decreased sleep latency and increased sleep stage. In these cases, the involvement of environmental factors was strongly suggested for the sleep-wake rhythm abnormalities as well as familial factors.