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[Phytoestrogens].

¹Faculty of Pharmaceutical Sciences, Fukuoka University.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|February 24, 2001

Summary

Soy isoflavonoids are metabolized by gut bacteria into compounds that interact with human estrogen receptors. These metabolites, particularly equol, show strong binding affinity and gene-expression activity, potentially impacting hormone-dependent diseases.

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Area of Science:

Phytoestrogen metabolism
Molecular endocrinology
Gut microbiome interactions

Context:

Soy isoflavonoids are dietary compounds with potential health benefits.
Epidemiological studies suggest a link between soy consumption and reduced risk of hormone-dependent diseases.
Human intestinal bacteria play a crucial role in metabolizing dietary compounds.

Purpose:

To review the metabolism of soybean isoflavonoids by human intestinal bacteria.
To investigate the binding and gene-expression activity of these metabolites with human estrogen receptors (hER) alpha and beta.

Summary:

Dietary isoflavones (daidzin, genistin) are converted to daidzein, genistein, equol, and dihydrogenistein by gut bacteria.
Metabolites exhibit differential binding affinities to hER alpha and hER beta, with stronger affinity for hER beta.
Genistein's binding affinity is comparable to 17 beta-estradiol, and equol strongly induces transcription via both hER subtypes.

Impact:

Understanding isoflavonoid metabolism and receptor interaction is key to their health effects.
Findings may inform dietary recommendations for preventing hormone-dependent diseases.
Highlights the significance of the gut microbiome in mediating the biological activity of dietary phytoestrogens.

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