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[Kawasaki disease].

U S Blom1, B Zeller, K V Perminow

  • 1Barneavdelingen Sentralsykehuset i Akershus 1474 Nordbyhagen.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|February 24, 2001
PubMed
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Kawasaki disease, a leading cause of acquired heart disease in children, can lead to coronary aneurysms. Intravenous immunoglobulin treatment showed rapid improvement and normalization of coronary changes in most patients.

Area of Science:

  • Pediatrics
  • Cardiology
  • Immunology

Background:

  • Kawasaki disease (KD) is the leading cause of acquired heart disease in children.
  • Diagnosis relies on clinical criteria, including prolonged fever, conjunctivitis, and mucocutaneous changes.
  • Coronary artery aneurysms occur in 20-25% of untreated patients.

Observation:

  • A case series of six pediatric patients with Kawasaki disease treated between 1980-1999.
  • Five patients received intravenous immunoglobulin (IVIG) therapy.
  • Clinical improvement and resolution of fever occurred within 24-48 hours post-IVIG.

Findings:

  • One patient developed a moderate coronary aneurysm.
  • Four patients exhibited coronary vasculitis.
  • All coronary abnormalities resolved within 17 months of treatment.

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Implications:

  • Intravenous immunoglobulin is effective in managing Kawasaki disease.
  • Early treatment may prevent or reverse coronary artery complications.
  • Prompt diagnosis and intervention are crucial for pediatric cardiac health.