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Updated: Aug 19, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
[Polycyclic aromatic hydrocarbons. II. Toxic effects]
Z Fiala1, L Borská, A Vyskocil
1Ustav hygieny a preventivního lékarstvi, Univerzita Karlova v Praze, Lékarská fakulta v Hradci Králové. fiala@lfhk.cuni.cz
Abstract:
Polycyclic aromatic hydrocarbons (PAH) represent dangerous environmental pollutants. Many of them have toxic and carcinogenic potential. Presented work summarizes most of available data on the absorption, metabolism and elimination of PAH. The second part of article contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. In the third part of article, the populations with higher susceptibility to exposure to PAH are described and the influences of chemical interaction of PAH to biological effects are mentioned.
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