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Updated: Sep 6, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

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Mechanisms of action of intravenous immunoglobulin (IVIG)

M D Kazatchkine1, B Bellon, S V Kaveri

  • 1INSERM U430 and Université Pierre et Marie Curie, H pital Broussais, Paris, France.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|February 24, 2001
PubMed

Therapeutic preparations of pooled normal polyspecific immunoglobulin G for intravenous use (intravenous immunoglobulin, IVIG) have been shown to be effective in the treatment of a number of autoimmune and systemic inflammatory conditions. IVIG prevents the occurrence of experimental autoimmune encephalomyelitis. Increasing evidence suggests that IVIG is of benefit in patients with relapsing-remitting multiple sclerosis. The present review discusses the immunoregulatory properties and mechanisms of action of IVIG in autoimmune disease.

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