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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...

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Updated: Jul 17, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Current thinking and treatment practices in anaemia--an interactive poll.

J L Spivak1, M Cazzola

  • 1The Johns Hopkins University, Baltimore, MD, USA. jlspivak@mail.jhmi.edu

Medical Oncology (Northwood, London, England)
|February 24, 2001
PubMed
Summary

Cancer patient anaemia significantly impacts quality of life. Most experts treat based on symptoms, not just haemoglobin levels, with varied approaches to recombinant human erythropoietin (rHuEPO) therapy initiation.

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A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
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Last Updated: Jul 17, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
05:35

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

Area of Science:

  • Hematology
  • Oncology
  • Clinical Practice

Background:

  • Anaemia is a common complication in cancer patients.
  • It significantly affects patient quality of life.
  • Current treatment practices for cancer anaemia vary.

Purpose of the Study:

  • To poll haematologists and oncologists on their views and practices regarding cancer anaemia.
  • To understand treatment triggers and the use of erythropoietin-stimulating agents.

Main Methods:

  • A poll using keypad technology was conducted at the EHA meeting.
  • Expert audience (haematologists and oncologists) participated.
  • Case studies were used to explore treatment practices.

Main Results:

  • Over 76% recognized anaemia's negative impact on quality of life.
  • A majority ( > 60%) prioritize symptoms over haemoglobin levels for treatment initiation.
  • There was no consensus on specific haemoglobin thresholds for treatment.
  • Most (54%) do not use serum erythropoietin levels to guide recombinant human erythropoietin (rHuEPO) therapy.

Conclusions:

  • Expert opinion highlights the significant burden of anaemia in cancer patients.
  • Treatment decisions are often symptom-driven rather than solely haemoglobin-based.
  • Practices regarding rHuEPO use and monitoring show considerable variability among specialists.