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[Is TT virus (TTV) a true hepatitis virus cause?].
1Instituto de Cardiología y Cirugía Cardiovascular, Fundación Favaloro, Buenos Aires, Argentina. medtrans@ffinme.edu.ar
Medicina
|February 24, 2001
Summary
TT virus (TTV), a widespread infectious agent, is frequently found in the general population. Despite initial suggestions of hepatotropism, TTV infection lacks consistent association with liver injury or disease.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Context:
- TT virus (TTV) identified in transfusion recipients negative for known hepatitis viruses.
- TTV exhibits hepatotropism, with titers correlating to elevated serum aminotransferase levels.
Purpose:
- To investigate the nature and clinical significance of TT virus (TTV).
- To determine the association between TTV DNA and liver injury.
- To understand TTV transmission routes and prevalence.
Summary:
- TTV DNA presence is not consistently linked to biochemical or histological evidence of liver injury.
- TTV is globally prevalent, with high rates in the general population.
- Transmission occurs via parenteral, enteral, and mother-to-child routes.
Impact:
- Challenges the classification of TTV as a primary hepatitis virus.
- Highlights the need for further research into TTV's role in human health.
- Informs public health strategies regarding TTV prevention and control.