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Updated: Sep 2, 2026
Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography
Published on: September 5, 2012
Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to
F Rodríguez de Fonseca1, A J Roberts, A Bilbao
1Instituto Complutense de Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, 28223-Madrid, Spain.
Aim:
To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration.
Methods:
We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10% v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers.
Results:
Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A.
Conclusion:
These results further support that cannabinoid CB1 receptor blockade may have a potential utility for the treatment of alcoholism.
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