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[An experimental study on the effect of xenogeneic bone combined with human recombinant bone morphogenetic protein-2]
Objective:
To determine the ability of a new type of composited xenogeneic bone to repair the bone defect.
Methods:
The new type of composited xenogeneic bone was obtained by combining the treated cancellous bone with recombinant human bone morphogenetic protein-2 (rhBMP-2) and was implanted in the bone defect of rabbit.
Results:
There were a large amount of new bone formation within the combined material and the amount was increasing as the time lapsed in the area of the bone defect. In contrast, there were a lot of fibrous tissues with a little new bone formed when the treated cancellous bone was implanted alone.
Conclusion:
The results imply that the rhBMP-2 plays a very important role in new bone formation and the composited xenogeneic bone appears to be an ideal material for the repair of bone defect.