[The relation between trace element selenium and osseointegration of titanium implants]

Titanium implants were placed bilaterally in the proximal tibia of thirty-six adult male rabbits to demonstrate the relation between trace element selenium and titanium implants osseointegration. The animals were randomly divided into the control group and the selenium adding group. There were eighteen animals in each group. In experimental group, Na2SeO3 10 micrograms/kg body weight was given intramuscularly everyday for 6 days postoperatively, Measurement of trace element selenium contents, histologic findings and mechanical testing were applied to evaluate the effect. The results showed that trace element selenium contents of bones around implants were positively related to the strength of the implant fixation. Selenium could obviously speed up the formation of implant osseointegration and significantly improve the strength of the implants fixation compared with the control group at 1 week and 4 weeks after implantation.