Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Experimental study on immune privilege in subretinal space].

L Gao1, D Jiang

  • 1Department of Ophthalmology, The Second Affiliated Hospital, Hunan Medical University, Changhsa 410011.

Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Test of CP Symmetry in the Neutral Decays of Λ via J/ψ→ΛΛ[over ¯].

Physical review letters·2026
Same author

Precise Measurement of the Chromoelectric Dipole Moment of the Charm Quark.

Physical review letters·2026
Same author

Precise Measurement of Matter-Antimatter Asymmetry with Entangled Hyperon-Antihyperon Pairs.

Physical review letters·2026
Same author

Observation of Λ[over ¯]p→K^{+}π^{+}π^{-}π^{0} and Λ[over ¯]p→K^{+}π^{+}π^{-}2π^{0}.

Physical review letters·2026
Same author

First Measurement of the D_{s}^{+}→K^{0}μ^{+}ν_{μ} Decay.

Physical review letters·2026
Same author

Observation of the Electromagnetic Radiative Decays of the Λ(1520) and Λ(1690) to γΣ^{0}.

Physical review letters·2026

Subretinal space transplantation shows limited immune privilege. While cytotoxic T lymphocyte activity increased, delayed-type hypersensitivity remained unchanged, indicating a degree of immune tolerance.

Area of Science:

  • Ophthalmology
  • Immunology
  • Transplantation Biology

Context:

  • The subretinal space is a potential site for cell-based therapies in retinal diseases.
  • Understanding its immune microenvironment is crucial for successful transplantation outcomes.

Purpose:

  • To investigate the immune characteristics of the subretinal space following transplantation.
  • To assess immune responses like delayed-type hypersensitivity and cytotoxic T lymphocyte activity.

Summary:

  • Transplantation of mouse retina, human peripheral blood mononuclear cells (PBMC), or syngenic retina into the subretinal space of BALB/C mice was performed.
  • Delayed-type hypersensitivity (DTH) showed no significant difference between groups and controls.
  • Cytotoxic T lymphocyte (CTL) specific killing was significantly elevated in transplanted groups compared to controls, with retinal transplants surviving and PBMCs eliciting immune rejection.

Related Experiment Videos

Impact:

  • The subretinal space exhibits a degree of immune privilege, suggesting potential for ocular transplantation.
  • Further research is needed to optimize conditions for sustained engraftment and therapeutic efficacy.