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Updated: Aug 10, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
[Changes of thyroid and adrenocortical functions after bone marrow transplantation with MAC conditioning regimen in
Objective:
To investigate the effect of MAC conditioning regimen on endocrine glands function in leukemia patients after bone marrow transplantation(BMT).
Methods:
Thyroid and adrenocortical functions were assayed by radioimmunoassay (RIA) in 26 leukemia patients before and after BMT.
Results:
All patients had normal thyroid and adrenocortical functions before BMT. As compared with that pre BMT, the median serum TSH levels were increased at 1, 3 and 6 months post BMT(P < 0.01). This thyroid dysfunctions were found in 7 of 26 patients, 6 of whom were recovered at 6 months post BMT.
Conclusion:
There was little effect of MAC conditioning regimen on adrenocortical function. Thyroid dysfunctions were found in 28% of the patients after BMT, and normalized in a short period without replacement therapy.
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