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Updated: Jul 31, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
[Aberrant expression of immunoglobulin germline gene C mu in leukemias]
Objective:
To investigate the significance of immunoglobulin germline gene C mu expression in leukemias.
Methods:
Immunoglobulin germline gene C mu transcripts in 63 bone marrow samples from 59 leukemia patients were examined by RT-PCR.
Results:
Germline C mu transcripts could be identified in 17 of 26 AML, 9 of 12 ALL, 4 CML-BC and 2 CLL patients. HLA-DR was expressed in 80% C mu(+) patients and in 92.9% C mu(+) AML patients. In 10 normal bone marrow or peripheral blood samples C mu transcripts were undetectable.
Conclusion:
Leukemogenesis in most acute leukemia may originate from the common progenitors of early B-lymphoid and myeloid cells.
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