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Related Experiment Videos

Angiogenesis in necrotic ulcers treated with hyperbaric oxygen.

M C Heng1, J Harker, G Csathy

  • 1Department of Medicine, VA Greater Los Angeles Healthcare System (Sepulveda), UCLA San Fernando Valley Program.

Ostomy/Wound Management
|February 24, 2001
PubMed
Summary

Topical hyperbaric oxygen therapy (THOT) significantly enhances healing for necrotic wounds by promoting blood vessel growth (angiogenesis). This treatment led to 90% wound healing, compared to 22% with standard care.

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Area of Science:

  • Wound healing
  • Vascular biology
  • Hyperbaric medicine

Background:

  • Necrotic and gangrenous wounds suffer from poor blood supply and can worsen with oxygen exposure at incorrect pressures.
  • Reperfusion injury and oxygen toxicity are significant concerns in managing these complex wounds.

Purpose of the Study:

  • To evaluate the efficacy of topical hyperbaric oxygen (THOT) in promoting angiogenesis and healing of necrotic/gangrenous wounds.
  • To compare THOT with standard wound care (SWC) in a prospective randomized study.

Main Methods:

  • A prospective randomized study involving 40 inpatients with 79 ulcers over 12 months.
  • Participants were randomized to receive either THOT (1.004-1.013 atmospheres) or SWC.
  • Ulcer size and capillary density (per high power field) were measured to assess healing and angiogenesis.

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Main Results:

  • A significantly higher healing rate was observed in the THOT group (90%) compared to the SWC group (22%).
  • Ulcer size at 4 weeks was significantly smaller in the THOT group than in the SWC group (P < 0.0001).
  • Capillary density was significantly increased in THOT-treated wounds compared to SWC wounds (P < 0.001).

Conclusions:

  • THOT is effective in stimulating angiogenesis, leading to enhanced healing of necrotic and gangrenous wounds.
  • The study confirms the therapeutic benefit of localized hyperbaric oxygen for challenging wound types.