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[A study of the oxidative stress indicators in elderly monkeys]
M E González-Fraguela1, M A Robinson, R Delgado
1Departamento de Neurobioquímica, Centro Internacional de Restauración Neurológica, CIREN, Ave. 25, # 15.805, e/158 y 160, Playa, CP 11300 La Habana, Cuba. mariae@neuro.sld.cu
Revista De Neurologia
|February 24, 2001
Summary
Aging in nonhuman primates is linked to altered oxidation metabolism and neurodegeneration. This study investigated the relationship between oxidative stress markers and tumor necrosis factor alpha (TNF-alpha) in aging monkeys.
Area of Science:
- Biomedical science
- Oxidative stress research
- Primate aging studies
Context:
- Aerobic cells produce reactive oxygen species, and cell survival hinges on the balance between oxidation and antioxidant defenses.
- Imbalances can lead to oxidative stress, a factor implicated in age-related neurodegeneration.
- Proinflammatory states and reduced oxidative metabolism are increasingly linked to cognitive decline in aging humans.
Purpose:
- To investigate the relationship between oxidative stress markers and tumor necrosis factor alpha (TNF-alpha) in nonhuman primates.
- To compare serum levels of superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and TNF-alpha in young and old nonhuman primates.
Summary:
- Serum levels of SOD, CAT, MDA, and TNF-alpha were measured in young and old nonhuman primates using spectrophotometric techniques.
- Results indicated alterations in oxidation metabolism in older primates.
- A potential link between these metabolic changes and neurodegenerative processes was suggested.
Impact:
- Provides insights into the biochemical mechanisms underlying age-related neurodegeneration in primates.
- Highlights the role of oxidative stress and inflammation in primate aging.
- Informs future research on interventions to mitigate age-related cognitive decline.