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Treatment update for allergic rhinitis.

M Frieri1

  • 1Department of Medicine and Pediatrics, Nassau University Medical Center, and State University of New York at Stony Brook, Stony Brook, New York, USA.

Allergy and Asthma Proceedings
|February 24, 2001
PubMed
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This study explores allergic rhinitis, focusing on inflammatory mediators, cytokines, and treatments like immunotherapy and topical steroids. It reviews pharmacotherapy, including antihistamines and anti-IgE therapies, for managing allergic rhinitis effectively.

Area of Science:

  • Immunology
  • Pharmacology
  • Allergy Research

Background:

  • Allergic rhinitis involves complex immunologic responses.
  • Understanding inflammatory mediators and cytokines is crucial for treatment.
  • Current treatments include immunotherapy, glucocorticosteroids, and antihistamines.

Purpose of the Study:

  • To review the pathogenesis of allergic rhinitis.
  • To discuss diagnostic methods like nasal provocation.
  • To evaluate current and emerging therapeutic options.

Main Methods:

  • Literature review of pathogenesis and inflammatory mediators.
  • Analysis of immunologic changes in allergen immunotherapy.
  • Pharmacological review of topical glucocorticosteroids, antihistamines, and anti-IgE therapies.

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Main Results:

  • Nasal provocation aids in assessing inflammatory mediators.
  • Cytokines play a significant role in allergic rhinitis.
  • Topical glucocorticosteroids and antihistamines are effective treatments.
  • Newer therapies like anti-IgE show anti-inflammatory potential.

Conclusions:

  • Effective management of allergic rhinitis requires understanding its pathogenesis and inflammatory pathways.
  • A range of therapeutic options, from immunotherapy to novel agents, are available.
  • Fexofenadine, azelastine, and anti-IgE therapies represent advancements in allergic rhinitis treatment.