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Validation of markers for their relevance to health and disease
1Groupe Danone, Le Plessis-Robinson, France.
Abstract:
Validation of markers requires two different steps. The first one is the analytical validation including analytical procedures, definition of standard reference, and round-tests analysis. The second one is the assessment of the biological relevance of the selected marker. This biological relevance may be in the field of physiology to measure a physiological function, or in the area of pathology to measure a disease. Validation of markers is a time-consuming task that needs cooperation between laboratories. On the other hand a validated marker is a keystone for scientists to share their results and to explore more efficiently a given biological system.
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