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Related Experiment Videos

ATP as a presynaptic modulator.

R A Cunha1, J A Ribeiro

  • 1Department of Chemistry & Biochemistry, Faculty of Sciences, Lisbon, Portugal. racunha@neurociencias.pt

Life Sciences
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

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Adenosine triphosphate (ATP) may function as a neurotransmitter in the central nervous system (CNS). This review explores evidence suggesting ATP acts presynaptically, challenging the traditional postsynaptic view of purinergic signaling.

Area of Science:

  • Neuroscience
  • Cellular signaling

Background:

  • Adenosine triphosphate (ATP) is recognized as a fast neurotransmitter or co-transmitter in peripheral autonomic and sensory nerves.
  • ATP exerts its effects via ionotropic P2X and metabotropic P2Y receptors.
  • ATP release from stimulated central nervous system (CNS) nerve terminals and responses in central neurons suggest a potential role in the CNS.

Purpose of the Study:

  • To review the evidence for ATP as a neurotransmitter in the CNS.
  • To investigate the localization of ATP's action within the nervous system, specifically presynaptic versus postsynaptic roles.

Main Methods:

  • Literature review of studies on purinergic signaling in the CNS.
  • Analysis of evidence regarding P2 receptor expression and ATP release in central neurons.

Related Experiment Videos

  • Evaluation of studies investigating presynaptic and postsynaptic effects of ATP.

    • Main Results:

    • While P2 receptor mRNA and binding are abundant in the CNS, direct evidence for central purinergic transmission has been limited.
    • Existing evidence suggests ATP may act presynaptically in the nervous system.
    • This challenges the conventional understanding of ATP's primary postsynaptic function.

    Conclusions:

    • ATP's role as a fast neurotransmitter in the CNS warrants further investigation.
    • Evidence supports a presynaptic role for ATP in central neurotransmission.
    • Re-evaluating purinergic signaling mechanisms in the CNS is necessary.