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Combined treatment with haloperidol and trazodone in patients with tic disorders
L Saccomani1, P Rizzo, L Nobili
1Child Neuropsychiatry, DSNV, G. Gaslini Institute, University of Genova, Italy. lfsdoc@tiscalinet.it
Journal of Child and Adolescent Psychopharmacology
|February 24, 2001
Abstract:
The combination of haloperidol and trazodone was evaluated in an open-label trial in 10 patients with chronic tic and Tourette's syndrome. We found a mean reduction of symptoms of 58.9% on the Yale Global Tic Severity Scale, with a statistically significant difference (p < 0.001) between the baseline and endpoint treatment conditions. This approach significantly reduces clinical symptoms, with the advantage of a lower dose of haloperidol than usual, with no side effects reported by the patients.